| 1. | D - amino acids as unnatural chiral products are important intermediates in the synthesis of products , such as - lactam semisynthetic antibiotics , antiviral agents , artificial sweeteners , pesticide , peptide hormones , and pyrethroids , etc . though bioconversion of d - amino acids using microbial cells has been realized in industrialization for decades , some limited factors hinder the development of d - amino acid production , and ultimately result in shortage of the raw material in the related industrial fields 目前,用微生物菌体转化生产d -型氨基酸的工艺路线已经产业化,但天然菌体转化工艺存在一些限制因素,阻碍了d -型氨基酸的扩大生产,导致产品短缺。因此,利用基因工程菌生物转化d -型氨基酸已成为世界氨基酸产业的新潮流。 |